Blar i forfatter "Pedersen, Torunn Annie"

Viser treff 1-10 av 10

    • Detection of Klebsiella pneumoniae human gut carriage: a comparison of culture, qPCR, and whole metagenomic sequencing methods 

      Lindstedt, Kenneth; Buczek, Dorota Julia; Pedersen, Torunn Annie; Hjerde, Erik; Raffelsberger, Niclas Peter; Suzuki, Yutaka; Brisse, Sylvain; Holt, Kathryn E.; Samuelsen, Ørjan; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-31)
      Klebsiella pneumoniae is an important opportunistic healthcare-associated pathogen and major contributor to the global spread of antimicrobial resistance. Gastrointestinal colonization with K. pneumoniae is a major predisposing risk factor for infection and forms an important hub for the dispersal of resistance. Current culture-based detection methods are time consuming, give limited intra-sample ...

    • The enterococcus cassette chromosome, a genomic variation enabler in enterococci 

      Sivertsen, Audun; James Peter, Jessin Janice; Pedersen, Torunn Annie; Wagner, Theresa; Hegstad, Joachim; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-07)
      Enterococcus faecium has a highly variable genome prone to recombination and horizontal gene transfer. Here, we have identified a novel genetic island with an insertion locus and mobilization genes similar to those of staphylococcus cassette chromosome elements SCCmec. This novel element termed the enterococcus cassette chromosome (ECC) element was located in the 3′ region of rlmH and encoded large ...

    • Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood 

      Wagner, Theresa; James Peter, Jessin Janice; Paganelli, Fernanda; Willems, Rob J.L.; Askarian, Fatemeh; Pedersen, Torunn Annie; Top, Janetta; de Haas, Carla; van strijp, Jos A. G.; Johannessen, Mona; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-03)
      <i>Enterococcus faecium</i> has undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure of <i>E. faecium</i> is characterized by a sharp distinction of clades, where the hospital-adapted lineage is primarily responsible for bacteremia. So far, factors that were identified in hospital-adapted strains and that promoted pathogenesis of nosocomial <i>E. faecium</i> ...

    • Fra lokalt til nasjonalt utbrudd av Pseudomonas aeruginosa 

      Asfeldt, anne mette; Myrbakk, Torni; Grimnes, Gro; Kildal, Anders Benjamin; Pedersen, Torunn Annie; Littauer, Pia; Bogetvedt, Tina; Kroken, Bjørn Anders; Nerskogen, Birgith Jørgensen; Høgli, June Utnes; Åsheim, Sandra Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-29)
      Utbrudd som rammer flere sykehus, krever god koordinering. Folkehelseinstituttets rolle i dette arbeidet bør styrkes, og vi trenger bedre systemer for utbruddsovervåking, rask tilgang til genteknologiske verktøy samt metoder for mikrobiologiske undersøkelser av miljø og utstyr.

    • Genomic characterization of multidrug-resistant ESBL-producing Klebsiella pneumoniae isolated from a Ghanaian teaching hospital 

      Agyepong, Nicholas; Govinden, Usha; Owusu-Ofori, Alex; Amoako, Daniel Gyamfi; Allam, Mushal; Janice, Jessin; Pedersen, Torunn Annie; Sundsfjord, Arnfinn; Essack, Sabiha (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-23)
      <p><i>Objectives - </i>This study delineated the clonal lineages, antibiotic resistome and plasmid replicon types in multidrug-resistant <i>K. pneumoniae</i> isolates from a teaching hospital in Ghana. <p><i>Methods - </i>Identification and antibiotic susceptibility testing were done using the MALDI-TOF MS and Vitek-2 automated system. Genomic DNA extraction was carried out using the NucliSens ...

    • Horizontal plasmid transfer among klebsiella pneumoniae isolates is the key factor for dissemination of extended-spectrum β-lactamases among children in Tanzania 

      Pedersen, Torunn Annie; Tellevik, Marit Gjerde; Kommedal, Øyvind; Lindemann, Paul Christoffer; Moyo, Sabrina John; Janice, Jessin; Blomberg, Bjørn; Samuelsen, Ørjan; Langeland, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
      Increased knowledge about the role of horizontal gene transfer is key to improve our understanding of the spread of antimicrobial resistance (AMR) in human populations. We therefore studied the dissemination of the <i>bla</i><sub>CTX-M-15</sub> extended-spectrum-β-lactamase (ESBL) gene in <i>Klebsiella pneumoniae</i> isolates obtained from stool samples from hospitalized children and healthy controls ...

    • Intraregional hospital outbreak of OXA-244-producing Escherichia coli ST38 in Norway, 2020 

      Lindemann, Paul Christoffer; Pedersen, Torunn Annie; Oma, Dorthea Hagen; Janice, Jessin; Grøvan, Fredrik; Chedid, Ghantous Milad; Hafne, Liv Jorunn; Josefsen, Ellen Haldis; Kacelnik, Oliver; Sundsfjord, Arnfinn; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      Infections with OXA-244-carbapenemase-producing Escherichia coli with sequence type (ST)38 have recently increased in Europe. Due to its low-level activity against carbapenems, OXA-244 can be difficult to detect. Previous assessments have not revealed a clear source and route of transmission for OXA-244-producing E. coli, but there are indications of non-healthcare related sources and community ...

    • Investigating the mobilome in clinically important lineages of Enterococcus faecium and Enterococcus faecalis 

      Mikalsen, Theresa; Pedersen, Torunn Annie; Willems, Rob J; Coque, Teresa M.; Werner, Guido; Sadowy, Eva; van Schaik, Willem; Jensen, Lars Bogø; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-10)
      Background: The success of Enterococcus faecium and E. faecalis evolving as multi-resistant nosocomial pathogens is associated with their ability to acquire and share adaptive traits, including antimicrobial resistance genes encoded by mobile genetic elements (MGE). Here, we investigate this mobilome in successful hospital associated genetic lineages, E. faecium sequence type (ST)17 (n=10) and ...

    • Nasjonalt utbrudd av Pseudomonas aeruginosa i sykehus forårsaket av ferdigfuktede ikke-sterile vaskekluter, Norge, 2021-2022 

      Gravningen, Kirsten Midttun; Ødeskaug, Liz Ertzeid; Utheim, Mari Nythun; Korpås, Julie Andrine; Jørgensen, Silje Bakken; Elstrøm, Petter; Lyrån, Birgitte; Jemtland, Rune; Kols, Nicola Isabelle; Kvaal, Siv Anita; Asfeldt, anne mette; Littauer, Pia; Kilhus, Kristin; Skutlaberg, Dag Harald; Pedersen, Torunn Annie; Hermansen, Nils Olav; Kacelnik, Oliver; Iversen, Bjørn Gunnar (Research report; Forskningsrapport, 2022-06)
      I november 2021 ble Folkehelseinstituttet varslet om at tre intensivpasienter hadde dødd av blodbaneinfeksjon med bakterien Pseudomonas aeruginosa ved Universitetssykehuset Nord-Norge i Tromsø i løpet av kort tid. De hadde identiske isolater forenlig med et klonalt utbrudd. Helgenomsekvensering viste at det var en ny sekvenstype, ST3875, som ikke har vært påvist i Norge eller andre land. Nye ...

    • Silenced vanA gene cluster on a transferable plasmid cause outbreak of vancomycin variable enterococci 

      Sivertsen, Audun; Pedersen, Torunn Annie; Larssen, Kjersti Wik; Bergh, Kåre; Rønning, Torunn Gresdal; Radtke, Andreas; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-02)
      We report an outbreak of vancomycin-variable vanA+ enterococci (VVE) able to escape phenotypic detection by current guide- lines and demonstrate the molecular mechanisms for in vivo switching into vancomycin resistance and horizontal spread of the vanA cluster. Forty-eight vanA+ Enterococcus faecium isolates and one Enterococcus faecalis isolate were analyzed for clonality with pulsed-field ...